| Rank | Name | Team | Matchup |
|---|---|---|---|
| Tier 1 | |||
| 1 | Jahmyr Gibbs | DET | NYG |
| 2 | Christian McCaffrey | SF | CAR |
| 3 | Jonathan Taylor | IND | @KC |
| 4 | Bijan Robinson | ATL | @NO |
| 5 | Derrick Henry | BAL | NYJ |
| Tier 2 | |||
| 6 | Rico Dowdle | CAR | @SF |
| 7 | James Cook | BUF | @HOU |
| 8 | Kyren Williams | LAR | TB |
| 9 | Saquon Barkley | PHI | @DAL |
| 10 | Treyveon Henderson | NE | @CIN |
| 11 | Javonte Williams | DAL | PHI |
| Tier 3 | |||
| 12 | Chase Brown | CIN | NE |
| 13 | Ashton Jeanty | LV | CLE |
| 14 | Travis Ettiene Jr | JAX | @ARI |
| 15 | Quinshon Judkins | CLE | @LV |
| 16 | Breece Hall | NYJ | @BAL |
| 17 | Woody Marks | HOU | BUF |
| Tier 4 | |||
| 18 | Deandre Swift | CHI | PIT |
| 19 | Jaylen Warren | PIT | @CHI |
| 20 | Aaron Jones Sr | MIN | @GB |
| 21 | David Montgomery | DET | NYG |
| 22 | Kareem Hunt | KC | IND |
| 23 | Emanuel Wilson | GB | MIN |
| 24 | Zach Charbonnet | SEA | @TEN |
| 25 | Alvin Kamara | NO | ATL |
| 26 | Sean Tucker | TB | @LAR |
| 27 | Kenneth Walker | SEA | @TEN |
| Tier 5 | |||
| 28 | Tyrone Tracy Jr | NYG | @DET |
| 29 | Bhayshul Tuten | JAX | @ARI |
| 30 | Tyler Allgeier | ATL | @NO |
| 31 | Rhamondre Stevenson | NE | @CIN |
| 32 | Kyle Monangai | CHI | PIT |
| 33 | Zonovan Knight | ARI | JAX |
| Tier 6 | |||
| 34 | Kenneth Gainwell | PIT | @CHI |
| 35 | Tony Pollard | TEN | SEA |
| 36 | Tyjae Spears | TEN | SEA |
| 37 | Rachaad White | TB | @LAR |
| 38 | Devin Singletary | NYG | @DET |
Home Week 12 RB Rankings