Welcome back, fantasy football fans! If you’re building lineups for DFS contests on FanDuel and DraftKings for September 28, 2025, today’s slate offers a mix of proven veterans and young breakout stars. Whether you’re playing cash games or chasing upside in tournaments, there’s plenty of value across positions. Let’s dive into the best DFS picks for today.
Top DFS Quarterback Picks
Caleb Williams (CHI) – FD $7,500 / DK $5,800
Williams is quickly becoming a go-to DFS quarterback. His dual-threat ability makes him a safe cash option, and at just $5,800 on DraftKings, he’s underpriced for his ceiling. Pair him with Rome Odunze for an affordable stack.
Geno Smith (LV) – FD $7,200 / DK $5,400
Looking for savings? Geno Smith provides tournament value. With the Raiders’ weapons around him, he’s capable of a multi-touchdown outing, especially against softer defenses.
Running Back Value Plays
James Cook (BUF) – FD $8,500 / DK $7,100
Cook headlines the RB pool today. His consistent role in both the run and pass game gives him one of the safest workloads on the slate. Expensive, but worth it in cash.
Omarion Hampton (LAC) – FD $7,000 / DK $5,900
Hampton is a standout mid-range play. He’s seeing red-zone usage and carries explosive upside if the Chargers’ offense clicks.
Ashton Jeanty (LV) – FD $6,800
Jeanty is priced for tournaments. If the Raiders commit to the ground game, he could smash value on FanDuel.
Treyveon Henderson (NE) – FD $5,700
At this price, Henderson is a GPP dart throw. He’ll need efficiency, but the opportunity is there.
Cam Skattebo (NYG) – FD $5,400
Near-minimum salary makes Skattebo a strong punt play. He opens up cap space for studs without killing your lineup.
Tony Pollard – DK $5,600
Pollard isn’t listed on FanDuel today, but he’s a DraftKings bargain. His ability to break a long run or catch out of the backfield gives him slate-breaking potential.
Wide Receiver Targets
Keenan Allen (LAC) – FD $6,500 / DK $5,300
Allen remains the reliable option. At these prices, he’s a strong play in both formats, especially in PPR scoring on DraftKings.
Quentin Johnston (LAC) – FD $6,200
Looking for tournament upside? Johnston’s big-play ability makes him an excellent pivot off Allen in large-field contests.
Rome Odunze (CHI) – FD $7,200
Odunze is quickly emerging as Caleb Williams’ top target. Strong stacking option if you’re building around the Bears’ passing attack.
Jacobi Meyers (LV) – FD $6,100
Meyers is a steady mid-tier WR. Not flashy, but his target volume keeps him relevant in cash builds.
Jauan Jennings (SF) – FD $5,900 / DK $5,000
Jennings is a sneaky value today. If his snap share holds, he’s underpriced for his role in San Francisco’s offense.
Michael Pittman (IND) – FD $5,800 / DK $5,100
One of the best DFS values on the slate. Pittman’s target share far exceeds his salary on both sites, making him a lock in many builds.
Tetairoa McMillan (CAR) – FD $5,800
McMillan’s red-zone usage makes him a strong contrarian option. Tournament players should have him in their pool.
Ricky Pearsall – DK $5,700
Priced higher than his volume suggests, Pearsall is GPP-only. He’ll need a big play to pay off.
Drake London – DK $5,700
London has the skill set to outperform his salary if Atlanta gets him more looks. Tournament upside only.
Tight End Plays
Zach Ertz (WAS) – FD $5,000
Ertz still commands steady targets and is a safe floor option. Solid cash play if you’re spending up a bit at TE.
Harold Fannin Jr. (CLE) – FD $4,800 / DK $3,700
Fannin is today’s best cheap tight end. His DraftKings salary makes him an excellent punt play, freeing up salary for studs.
Kyle Pitts (ATL) – DK $3,600
Tournament-only. Pitts remains boom-or-bust, but if he finally gets the usage, he could break a slate.
David Njoku (CLE) – DK $3,800
Njoku offers a safer floor than Pitts and is priced affordably. Solid mid-range DK play.
DFS Strategy for September 28, 2025
- Cash Games: Stick with Caleb Williams, James Cook, Keenan Allen, and Michael Pittman for safe floors.
- Tournaments (GPPs): Mix in Geno Smith stacks with Jacobi Meyers or Ashton Jeanty, and don’t ignore high-upside WRs like Quentin Johnston or Rome Odunze.
Today’s slate is about balancing value plays with proven volume. Load up on reliable targets in cash, and take some shots on upside receivers and mid-tier RBs in tournaments.
Final Word
That’s your DFS breakdown for September 28, 2025. Whether you’re playing on FanDuel or DraftKings, building around the right mix of safe veterans and upside plays will give you the edge. Good luck in your contests, and let’s cash those lineups!
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